Figure 2. Osteocyte-specific deletion of Fgf23 fully corrects hypophosphatemia in Dmp1^KO mice.

Serum levels of (A) total FGF23 (cFGF23), (B) intact FGF23 (iFGF23), (C) intact to total FGF23 ratio (i/c FGF23), (D) parathyroid hormone (PTH), (E) 1,25-dihydroxyvitamin D [1,25(OH)₂D], (F) calcium (Ca²⁺), and (G) phosphate (Pi); (H) fractional excretion of Pi (FePi); and kidney mRNA expression of (I) NaPi2a, (J) Cyp27b1, and (K) Cyp24a1 in 12-week-old WT (n ≥ 5), Fgf23^Dmp1-cKO (n ≥ 5), Dmp1^KO (n ≥ 3), and Dmp1^KO Fgf23^Dmp1-cKO (n ≥ 5) mice. Values are expressed as mean ± SEM; P < 0.05 vs. ^aWT, ^bFgf23^cKO, ^cDmp1^KO. Statistical tests were ANOVA test followed by post hoc t tests and multiple-testing correction using Holm-Bonferroni method.