Figure 3. Osteocyte-specific deletion of Fgf23 partially corrects bone growth in Dmp1^KO mice.

(A) Mouse gross appearance, (B) body weight, (C) tail length, (D) femur length, (E) femur gross appearance, and (F) 3D μCT representation of total femur in sagittal plane (scale bar = 1 mm) in 12-week-old WT (n ≥ 6), Fgf23^Dmp1-cKO (n ≥ 5), Dmp1^KO (n ≥ 5), and Dmp1^KO Fgf23^Dmp1-cKO (n ≥ 4) mice. Values are expressed as mean ± SEM; P < 0.05 vs. ^aWT, ^bFgf23^cKO, ^cDmp1^KO. Statistical tests were performed using ANOVA test followed by post hoc t tests and multiple-testing correction using Holm-Bonferroni method.