TABLE 1.

Baseline characteristics.

Variables	MEFIB-negative, N = 193 (65%)	MEFIB+ and MRI-PDFF ≥5%, N = 79 (27%)	MEFIB+ and MRI-PDFF <5%, N = 24 (8%)	p-value
Age, years (SD)	52.8 (13.5)	65.1 (8.4)	66.9 (7.3)	<0.0001
Male, n (%)	86 (44.6)	34 (43.0)	11 (45.8)	0.9613
Diabetes, n (%)	85 (44.0)	57 (72.2)	19 (82.6)	<0.0001
Hypertension, n (%)	62 (32.1)	36 (45.6)	16 (66.7)	0.0015
Dyslipidaemia, n (%)	106 (55.5)	45 (57.0)	9 (37.5)	0.2160
BMI (kg/m2), mean (SD)	30.1 (6.0)	28.4 (5.1)	28.9 (4.1)	0.0740
Race, n (%)
White	72 (37.3)	19 (24.1)	12 (50.0)	0.1285
Hispanic	25 (13.0)	10 (12.7)	4 (16.7)
Asian	91 (47.2)	49 (62.0)	8 (33.3)
Others	5 (2.6)	1 (1.3)	0 (0)
AST (U/L), median (IQR)	29.0 (18.5)	47.0 (36.0)	34.5 (30.5)	<0.0001
ALT (U/L), median (IQR)	41.0 (36.5)	42.0 (41.0)	29.0 (25.0)	0.1324
Total bilirubin (mg/dL), median (IQR)	0.40 (0.32)	0.60 (0.51)	0.92 (0.93)	<0.0001
Albumin (g/dL), median (IQR)	4.5 (0.4)	4.3 (0.5)	4.2 (0.5)	<0.0001
Creatinine (mg/dL), median (IQR)	0.77 (0.16)	0.80 (0.26)	0.69 (0.38)	0.0251
Triglycerides (mg/dL), median (IQR)	169.0 (111.0)	163.0 (92.0)	142.0 (88.5)	0.1046
HDL (mg/dL), median (IQR)	48.0 (11.5)	47.0 (13.0)	45.4 (18.0)	0.2395
LDL (mg/dL), median (IQR)	129.5 (40.0)	120.0 (35.0)	101.0 (45.0)	0.0003
HbA1c (%), median (IQR)	6.1 (0.9)	6.5 (1.7)	6.5 (1.4)	0.0111
Platelet count (109/L), median (IQR)	249.0 (81.5)	150.0 (87.0)	123.5 (59.0)	<0.0001
PT INR, median (IQR)	1.00 (0.06)	1.04 (0.11)	1.13 (0.23)	<0.0001
FIB-4, median (IQR)	1.08 (0.75)	3.06 (2.02)	4.08 (2.28)	<0.0001
MRE (kPa), mean (SD)	2.90 (1.09)	5.37 (1.51)	5.92 (1.64)	<0.0001
MRI-PDFF, mean (SD)	13.15 (8.09)	12.07 (6.19)	3.18 (0.87)	<0.0001

Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; BMI, body mass index; HbA1c, Haemoglobin A1c; HDL, high-density lipoprotein; IQR, interquartile range; LDL, low-density lipoprotein; FIB-4, fibrosis index based on the 4 factor; MEFIB, MRI combined with FIB-4; MRE, magnetic resonance elastography; MRI-PDFF, magnetic resonance imaging derived proton density fat fraction; PT INR, prothrombin time international normalised ratio; SD, standard deviation.