Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 14;14(4):455–466. doi: 10.1177/19476035221142011

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 1. — The schematic drawing of GPX4-dependent ferroptosis and target of RTAs. GPX4 = glutathione peroxidase 4; RTA = radiotrapping antioxidant; SLC3A2 = solute carrier family 3 membrane 2; SLC7A11 = solute carrier family 7 membrane 11; P53 = protein 53; GSH = glutathione; GSR = glutathione reductase; GSSG = oxidized glutathione; PUFA = polyunsaturated fatty acid; ACSL4 = acyl-CoA synthetase long-chain family member 4; LPCAT3 = lysophophatidylcholne acyltransferase 3; PUFA-CoA = polyunsaturated fatty acid coenzyme A; PL = phospholipid; TfR1 = transferrin receptor 1; Fe²⁺ = ferrous iron; Fe³⁺ = ferric iron; DMT1 = divalent metal transporter 1; DFO = deferoxamine.