Table 1.

Protein Misfolding Diseases and Associated Aggregates and Sources of Proteotoxicity. The table indicates the protein misfolding diseases, aggregated proteins associated with each disease that are discussed in this review paper, as well as evidence and causes of proteotoxic stress caused by the aggregates associated with each disease.

Term	Abbreviation
Alzheimer’s Disease	AD
Amyloid Precursor Protein	APP
Amyloid β	Aβ
Amyotrophic Lateral Sclerosis	ALS
Conditional Knockout	cKO
Deubiquitinase(s)	DUB(s)
Endoplasmic Reticulum	ER
ER-associated Degradation	ERAD
Fused in Sarcoma	FUS
Htt53Q	Huntingtin 53Q
Human Islet Amyloid Polypeptide	hIAPP
Huntingtin	Htt
Huntington’s Disease	HD
Inclusion Bodies	IBs
Insoluble Protein Deposit	IPOD
Juxtanuclear Quality Control Compartment	JUNQ
Knockout	KO
Lipopolysaccharide	LPS
Parkinson’s Disease	PD
Poly Glycine Alanine	polyGA
Polyglutamine	polyQ
Polyubiquitin	polyUb
Proteasome Stress Response	PSR
Protein Quality Control	PQC
Small-Ubiquitin-Related Modifier	SUMO
SUMO-targeted Ubiquitin Ligase	StUBL
Superoxide Dismutase 1	SOD1
TAR DNA-binding Protein 43	TDP-43
Ubiquitin	Ub
Ubiquitin Proteasome System	UPS
Ubiquitin-like protein(s)	UBL(s)
Unfolded Protein Response	UPR
Wildtype	WT