Figure 2. The total frequency of the combinations of mutations found in our isolate data for sets of four mutations (a) N51I, C59R, S108N, and I164L in P. falciparum dihydrofolate reductase (PfDHFR), and (b) N50I, S58R, S117N, and I173L in P. vivax DHFR (PvDHFR).

All frequencies have been multiplied by a factor of 10 to enable clear identification of those mutations occurring in one isolate only. The frequencies are also given as the percentage of the total number of isolates, which for PfDHFR is 6762 and PvDHFR is 847.