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. 2006 May;13(3):254–258. doi: 10.1101/lm.191706

Figure 2.

Figure 2.

CTA extinction learning is dependent on protein synthesis in the vmPFC. (A) Animals microinfused with anisomycin (100 μg/0.5 μL) into the vmPFC immediately following test day 1 showed marked aversion to saccharin compared with the vehicle animals throughout the experiment (*P < 0.05), except for the first test day (before drug infusion) and the last test day (day 6). Arrow denotes time of drug microinfusion. (B) Animals microinfused with anisomycin into the vmPFC immediately following the first exposure to saccharin and that received an i.p. injection of saline (instead of LiCl) were not significantly different from vehicle animals in their aversion to saccharin. (C) Animals microinfused with anisomycin into the vmPFC following exposure to saccharin on conditioning day were not significantly different from vehicle animals in their aversion to saccharin.