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. 2023 Nov 20;123(1):68–79. doi: 10.1016/j.bpj.2023.11.019

Figure 1.

Figure 1

The structural topology and location of the tryptophan and tyrosine residues mapped onto the NMR-derived model of DsbB reconstituted in a dark nanodisc (PDB: 2K73). DsbB is reconstituted in a dark nanodisc system loaded with DMPC and DMPG lipids at a 3:2 molar ratio and the nonfluorescent MSP. The four transmembrane domains are labeled TMD1–TMD4 and the interloop disulfide bond C41–C130 is shown in yellow. The C41–C130 interloop disulfide bond connects the two periplasmic loops. We also show the tryptophan and tyrosine residues as purple spheres for visualization.