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. 2023 Nov 29;625(7996):788–796. doi: 10.1038/s41586-023-06884-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 10 — a, Distribution of the pairwise (human versus mouse, human versus opossum, mouse versus opossum) shifts in the center of mass values of the trajectories that were assigned to preserved, human-specific, mouse-specific, marsupial and diverse patterns groups. The scheme (right) shows examples of a preserved pattern, a change in the human lineage, and a diverse pattern that cannot be assigned to a lineage. The changes in genes that differ between eutherians and opossum (marsupial) cannot be polarized. b, Distribution between trajectory clusters for genes with changes in gene expression trajectories during granule cell (left) or Purkinje cell (right) differentiation. c, Scatter plot of minimum and maximum pairwise distances between the expression trajectories of orthologues from the three species in Purkinje cell differentiation. High maximum and low minimum distances indicate the strongest lineage-specific trajectory changes. d, Examples of genes that display cross-species differences in trajectories during Purkinje cell differentiation.