Extended Data Fig. 8. An analogous fold-switch state is predicted for some Mpt53 structure homologues.

6 of the 10 screened homologues from DALI⁹¹ with the lowest RMSD to the original state predicted an alternate state similar to that of Mpt53. a) Conformational landscapes, visualized by RMSD to two states of Mpt53, and showing the corresponding known structures (above) and predicted alternate structures (below), coloured analogously to Mpt53 (cf. Fig. 5e). b) Alternate structures in (a), coloured by plDDT. c) Conformational landscapes of 4 structure homologues with no evidence for predicted alternate state.