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. 2024 Jan 10;625(7996):768–777. doi: 10.1038/s41586-023-06899-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a,b, Immunofluorescence images of whole mounts of the dorsal and ventral portions of nasopharyngeal lymphatic plexus (NPLP) stained for VE-cadherin (VE-cad) and LYVE1 in adult (8–10 weeks old) Prox1-GFP mice. White and yellow dashed-line box areas are enlarged in the centre and right panels. Blood capillaries are highlighted in pink. Zipper-like intercellular junction (magenta arrowheads) predominated (95%) in lymphatics with little or no LYVE1 staining, whereas button-like intercellular junctions (blue arrowheads) were more numerous (21%) in LYVE1⁺ lymphatics. Scale bars, 100 μm. Similar findings were obtained from n = 4 mice in two independent experiments. Bars indicate mean ± s.e.m. P values for junctions in LYVE1^- and LYVE1⁺ lymphatics were calculated by two-way ANOVA test followed by two-tailed Holm-Sidak’s multiple comparison post-hoc test.