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. 2024 Jan 10;625(7996):768–777. doi: 10.1038/s41586-023-06899-4

Extended Data Fig. 5. Lymphatics in upstream lymphatics region #2 along the pterygopalatine artery reach the nasopharyngeal lymphatic plexus through the posterior nasal plexus.

Extended Data Fig. 5

a, Diagram of sagittal view of upstream lymphatics region #2. b, Light-sheet fluorescence microscopic images showing serial optical sections (numbered) of lymphatics (outlined with green-dotted lines marked by white arrowheads) along the pterygopalatine artery (PPA, outlined with red-dotted lines) en route to the posterior nasal (green arrows) and nasopharyngeal lymphatic plexuses. A valve (green arrowhead) is located where lymphatics along the PPA join the posterior nasal lymphatic plexus. The white asterisk marks a segment of lymphatic with unknown connections. Anatomical positions are indicated in the upper right corner. Scale bars, 200 μm. Similar findings were obtained from n = 5 mice in three independent experiments. Ant., anterior; Post., posterior; Med., medial; Lat., lateral anatomical position. c, Fluorescence images of sections showing Prox1+ lymphatics in upstream lymphatics region #2 containing FluoSpheres (red arrowheads) along the PPA. Tuft cells of the olfactory epithelium are Prox1+. Anatomical positions are indicated in the upper right corner. Scale bar, 200 μm. Similar findings were obtained from n = 3 mice in two independent experiments. Ant., anterior; Post., posterior; Med., medial; Lat., lateral anatomical position.