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. 2024 Jan 10;625(7996):768–777. doi: 10.1038/s41586-023-06899-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Diagram of experimental sequence of intracisternal (i.c.) infusion of TMR-Dextran at 1.0 μl/min for 3 min, removal of injection needle, topical application of phenylephrine (PE) or sodium nitroprusside (SNP) to deep cervical lymphatics, and measurement of TMR-Dextran fluorescence in deep cervical lymph nodes (dcLN) of Prox1-GFP mice. b,c, Fluorescence images and measurements of TMR-Dextran fluorescence in dcLNs (outlined by green dashed lines) at 30 min after application of multiple concentrations of PE or SNP. Scale bars, 200 μm. Each dot is the value for one mouse; PBS (n = 18), 10 nM PE (n = 10), 1 μM PE (n = 10), 5 mM PE (n = 7), 3 μM SNP (n = 8), 30 μM SNP (n = 10) in five independent experiments. Error bars indicate mean ± s.e.m. AU, arbitrary unit. P values were calculated by two-way ANOVA test followed by two-tailed Dunnett’s T3 multiple comparison post-hoc test.