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. 2024 Jan 10;625(7996):768–777. doi: 10.1038/s41586-023-06899-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 13 — a, UMAP plot visualizing five subclusters of lymphatic endothelial cells (LECs) in the nasopharyngeal mucosa of adult (10-12 weeks old) mice. Pentraxin-3 (Ptx3), Ptx3⁻ capillary LECs (Ptx3⁻ Cap), Ptx3⁺ capillary LECs (Ptx3⁺ Cap), pre-collecting LECs (Pre-col), upstream valve LECs (up-valve), downstream valve LECs (down-valve). Total number of LECs analysed = 842. b, Heatmap showing differential expression of genes for the five subclusters of LECs. c, Violin plots comparing the expression of ten representative genes in the five sub-clusters. Little difference was found in Cdh5 or Prox1 among the subclusters, but Ptx3, Stab2, Foxp2, LYVE1, Cldn11, and Gja4 had prominent cluster-related differences.