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. 2024 Jan 10;625(7996):768–777. doi: 10.1038/s41586-023-06899-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 14 — a, Heatmap showing 50 differentially expressed genes in LECs of the nasopharyngeal mucosa of adult (10–12 weeks old) and aged (73–80 weeks old) mice. The total number of LECs analysed is 1,498. b, Violin plots showing as examples seven genes that were differentially expressed in adult and aged mice. Aged mice has higher expression of genes Irf7, Ifitm2, Ifitm3, and Zbp1 involved in the type I interferon response. P values were calculated by two-tailed MAST with Bonferroni post hoc test or two-tailed Wilcoxon rank test.