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. 2024 Jan 24;14:2061. doi: 10.1038/s41598-024-52667-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Nuclear Msh3 mRNA pool that is not accessible by MSH3 di-siRNA. (A) The graph demonstrates the linear correlation between striatal MSH3 mRNA and protein levels in Hdh^Q111/+ mice post 10 nmol MSH3 di-siRNA treatment. The correlation coefficient (R²) is 0.61, with a Y-intercept at 43.2 and a 95% confidence interval ranging from 29.8 to 56.6 (p < 0.001). (B) The linear correlation between cortical Msh3 mRNA and protein levels is depicted, presenting a correlation coefficient (R²) of 0.81, a Y-intercept at 14.0, and a 95% confidence interval from − 3.7 to 31.6 (p < 0.001). (C) Msh3 mRNA (red) localization in striatum and cortex detected with RNAscope post vehicle and 10 nmol MSH3 di-siRNA treatment. Nuclei stained with Hoechst 33342 (blue). Arrows indicate nuclei with nuclear Msh3 mRNA. The second and fourth columns display higher magnification views of the regions outlined by white boxes in the first and third columns, respectively.