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. 2024 Jan 24;14:2061. doi: 10.1038/s41598-024-52667-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-dependent reduction of somatic repeat expansion index by silencing Msh3 using di-siRNA in Hdh^Q111/+ mice. (A) Representative fragment analysis traces showing somatic CAG repeat expansions in the striatum of Hdh^Q111/+ at 3 months of age, and untreated, treated ICV with vehicle, 3 nmol di-siRNA, and 10 nmol di-siRNA at 6 months of age. (B) Quantification of the somatic expansion index in the striatum (STR), cortex (CTX), cerebellum (CEB) and liver (LIV). Error bars represent mean ± SD; n = 10. One-way ANOVA with Tukey’s post hoc analysis, *p < 0.05, **p < 0.01, ***p < 0.0001 and ****p < 0.0001.