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. 2024 Jan 11;11:1328875. doi: 10.3389/fcell.2023.1328875

FIGURE 2.

FIGURE 2

Critical developmental stage of the peripheral cholinergic synapse, the neuromuscular junction. The diagram is intended to emphasize the change occurring within a time window of 24 h between embryonic day 13 (E13) and embryonic day 14 (E14), during which individual nAChR molecules associate to form nanoclusters consisting of a few nAChR molecules. The nerve endings arrive during postnatal life (lower diagram), leading to the establishment of the neuromuscular junction (see (Sanes and Lichtman, 2001) for a review).