TABLE 7.
Stimulation of different IgG isotypes by PspA–IL-2 and PspA–GM-CSF after s.c. injectiona
| Immunogen | Anti-PspA ELISA titer
|
||
|---|---|---|---|
| IgG1 | IgG2a | IgG3 | |
| PspA | 1,407 | <50 | 62 |
| PspA–IL2 | 35,000 | 14,632 | 3,056 |
| PspA–GM-CSF | 17,387 | 617 | 894 |
a
Groups of five DBA/2 mice were immunized s.c. with PspA–IL-2 (5 μg), PspA–GM-CSF (10 μg), or PspA (10 μg) on days 0, 7, and 14. Mice were bled 14, 28, and 44 days later, and anti-PspA titers were determined by ELISA. Results are from one of three representative experiments.