Table 6.
Tissue cell populations.
| Healthy donors (n = 500) |
Achalasia (all) (n = 189) |
Type I (n = 59) |
Type II (n = 123) |
Type III (n = 7) |
|
|---|---|---|---|---|---|
| Tissue cell populations | |||||
| IL-22-expressing cells (%) mean ± SD | 3 ± 1 | 14 ± 7 | 7 ± 4 | 15 ± 4 | 29 ± 6 |
| Median | 3 | 15 | 6 | 16 | 28 |
| Range | 2.0–5.5 | 4.0–35.0 | 4.0–18.0 | 7.0–22.0 | 21.0–35.0 |
| IL-17A-expressing CD4 T cells (%) mean ± SD | 1.1 ± 0.9 | 12 ± 5 | 12 ± 3 | 8 ± 1 | 19 ± 3 |
| Median | 1 | 10.3 | 12 | 8 | 19 |
| Range | 0.0–2.0 | 7.0–22.0 | 9.0–19.5 | 7.0–11.0 | 16.0–22.0 |
| IL-4-expressing CD4 T cells (%) mean ± SD | 1.6 ± 0.7 | 7 ± 6 | 4 ± 1 | 3.5 ± 0.6 | 17.8 ± 0.8 |
| Median | 1.5 | 4 | 4 | 3.5 | 18 |
| Range | 1.0–3.0 | 2.0–19.0 | 3.0–5.0 | 2.0–4.0 | 17.0–19.0 |
| IFN--expressing CD4 T cells (%) mean ± SD | 2 ± 1 | 9 ± 7 | 14 ± 2 | 4.8 ± 0.5 | 18 ± 6 |
| Median | 1.5 | 5.7 | 13 | 6 | 15 |
| Range | 0.5–3.5 | 3.5–29.0 | 12.5–16.0 | 3.5–6.0 | 13.0–29.0 |
| Foxp3-expressing CD25 T cells (%) mean ± SD | 4.4 ± 0.6 | 7 ± 3 | 6 ± 3 | 7 ± 3 | 10 ± 2 |
| Median | 4.5 | 8 | 7.5 | 7.5 | 10 |
| Range | 3.5–5.0 | 3.0–13.5 | 2.3–9.0 | 2.0–13.5 | 8.0–13.0 |
| IL-10-expressing CD20 B cells (%) mean ± SD | 1.7 ± 0.5 | 6 ± 3 | 14 ± 7 | 4.5 ± 0.8 | 10 ± 2 |
| Median | 1.5 | 4.5 | 15 | 4.5 | 10 |
| Range | 1.0–2.5 | 3.0–12.0 | 4.0–35.0 | 3.5–6.5 | 7.0–12.0 |
| IDO-expressing CD123 cells (%) mean ± SD | 3.8 ± 0.7 | 7 ± 2 | 3.7 ± 0.6 | 3.7 ± 0.6 | 10 ± 2 |
| Median | 3.8 | 6 | 4 | 4 | 10 |
| Range | 3.0–4.0 | 4.0–13.0 | 3.0–4.0 | 3.0–4.0 | 9.0–13.0 |
| GAD65-expressing cells (%) mean ± SD | 0.3 ± 1.3 | 39 ± 22 | 44 ± 19 | 31 ± 10 | 70 ± 12 |
| Median | 0 | 33.2 | 44.3 | 32 | 68.3 |
| Range | 0.0–5.3 | 6.3–83.0 | 16.0–67.0 | 6.3–63.3 | 58.7–83.0 |
| PNMa/Ta2-expressing cells (%) mean ± SD | 0.3 ± 1.1 | 24 ± 12 | 22 ± 8 | 22 ± 5 | 47 ± 20 |
| Median | 0 | 21.7 | 12.6 | 19.9 | 43.3 |
| Range | 0.0–4.3 | 0.0–74.7 | 0.0–74.7 | 0.0–60.7 | 28.7–68.7 |
| S100-expressing cells (%) mean ± SD | 9 ± 7 | 22 ± 4 | 20 ± 4 | 20 ± 4 | 52 ± 20 |
| Median | 10 | 18 | 18 | 13.3 | 55.7 |
| Range | 0.0–19.3 | 0.0–69.7 | 0.0–51.3 | 0.0–54.0 | 30.3–69.7 |
| P Substance-expressing cells (%) mean ± SD | 1 ± 2 | 1.7 ± 0.5 | 2.2 ± 0.7 | 1.6 ± 0.9 | 0.6 ± 0.4 |
| Median | 0.2 | 0.6 | 1 | 0 | 0.3 |
| Range | 0.0–7.3 | 0.0–16.3 | 0.0–7.7 | 0.0–16.3 | 0.3–1.0 |
| VIP cells (ganglion cells)/cm2 (%) mean ± SD | 60 ± 21 | 1.4 ± 0.6 | 0.9 ± 0.4 | 0.4 ± 0.4 | 0.0 ± 0.0 |
| Median | 55.9 | 1 | 0 | 0 | 0 |
| Range | 35.0–105.3 | 1.0–14.0 | 0.0–4.0 | 0.0–7.8 | 0.0–0.0 |
| Interstitial cells of Cajal (c-Kit)/cm2(%) mean ± SD | 338 ± 144 | 96 ± 22 | 127 ± 42 | 98 ± 29 | 4 ± 4 |
| Median | 314.7 | 52.2 | 71.5 | 49 | 5 |
| Range | 190.9–776.2 | 0.0–608.4 | 7.0–608.4 | 7.8–479.0 | 0.0–7.0 |
| MMP-9 3G12-expressing cells (%) mean ± SD | 4 ± 2 | 11 ± 9 | 14 ± 10 | 11 ± 1 | 5 ± 2 |
| Median | 4.2 | 9.8 | 14.5 | 9.5 | 6.2 |
| Range | 0.0–5.7 | 0.7–4.7 | 4.3–46.3 | 0.7–40.7 | 3.0–6.3 |
| MMP-9 2D9-expressing cells (%) mean ± SD | 0.4 ± 0.9 | 0.9 ± 0.2 | 0.7 ± 0.3 | 1.2 ± 0.4 | 0.8 ± 0.2 |
| Median | 0 | 0.3 | 0.2 | 0.3 | 0.7 |
| Range | 0.0–3.0 | 0.0–4.7 | 0.0–4.3 | 0.0–4.7 | 0.7–1.0 |