Table 2:

Comparisons of region-specific cubic root-transformed WMH between CN, EOAD, EOnonAD participants presented as t-statistic (p-value). All p-values are computed using t-tests and are corrected for multiple comparisons using the FDR correction. The average (SD) WMH volumes are presented in Supplementary Table S1.

Region		CN vs EOAD	EOAD vs EOnonAD	CN vs EOnonAD
Frontal	Left	−5.1 (<0.001)	2.95 (0.005)	−1.33 (0.50)
Frontal	Right	−4.05 (<0.001)	2.34 (0.025)	−0.99 (0.50)
Temporal	Left	−4.49 (<0.001)	1.87 (0.069)	−1.61 (0.50)
Temporal	Right	−3.03 (0.027)	1.52 (0.13)	−0.98 (0.50)
Parietal	Left	−6.04 (<0.001)	4.94 (<0.001)	−0.51 (0.76)
Parietal	Right	−6.84 (<0.001)	4.48 (<0.001)	−1.43 (0.50)
Occipital	Left	−3.94 (<0.001)	3.72 (<0.001)	0.27 (0.79)
Occipital	Right	−4.51 (<0.001)	4.2 (<0.001)	0.3 (0.79)
Sum	Left	−5.95 (<0.001)	4.19 (<0.001)	−0.94 (0.50)
Sum	Right	−5.66 (<0.001)	3.72 (<0.001)	−1.08 (0.50)