Table 1.
Association of tumor-infiltrating and circulating γδ T cells with prognosis or survival of patients with different cancers.
| Cancer type | TILs or circulating lymphocytes | γδ T cell subtype | References |
|---|---|---|---|
| Studies supporting positive correlation with prognosis or survival | |||
| melanoma* | TIL | Vδ1+, Vδ2+ | (17, 33) |
| gastric cancer | TIL | unknown | (34) |
| breast cancer* | TIL | Vδ1+, Vδ2- | (35) |
| colorectal cancer* | TIL | Vγ9Vδ2 | (36) |
| prostate cancer | circulating | Vγ9Vδ2 | (37) |
| acute myeloid leukemia, acute lymphoblastic leukemia | circulating | Vδ1+ | (38) |
| lymphoma | circulating | Vγ9Vδ2 | (39) |
| B cell chronic lymphocytic leukemia | circulating | Vδ1+ | (40) |
| Studies supporting negative correlation with prognosis or survival | |||
| breast cancer* | TIL | Vδ1+ Tregs | (41) |
| pancreatic ductal adenocarcinoma | TIL | Vγ9Vδ2- | (29) |
| colorectal cancer* | TIL | Vδ1+ Tregs | (28) |
| squamous cell carcinoma | TIL | Vδ1+ and Vδ2+ Tregs | (42) |
| melanoma* | circulating | Vδ1+ | (43) |
Asterisks (*) highlight cancer types in which γδ T cells are associated with both positive and negative prognosis or survival. TIL, tumor-infiltrating lymphocytes; Tregs, regulatory T cells.