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. 2024 Jan 11;13:1325144. doi: 10.3389/fcimb.2023.1325144

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Copyright © 2024 Zheng, Lu, Zhou, Deng, Liu, Liu, Zhang, Li, Zheng and Dai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of anti-tumor mechanisms of T. cruzi. T. cruzi strains can kill tumor cells either by preferentially invading tumor cells or by activating T cells. More importantly, multiple specific components of TcCRT exert anti-tumor effects in multiple aspects. As a representative, TcCRT not only promotes antigen presentation of dendritic cells, but also plays an important role in anti-angiogenesis. T. cruzi, Trypanosoma cruzi; CTLA-4, cytotoxic T-lymphocyte antigen 4; CD4/8, cluster of differentiation 4/8; IL-12, interleukin-12; DCs, dendritic cells; TcCRT, T. cruzi calreticulin; rP21, recombinant P21; CXCR, C-X-C motif chemokine receptor.