Table 1.
Summary of levels of evidence for target proteins for DR and PDR.
| Disease | Protein | Discovery | Replication | Heterogenity | Pleiotropy | Colocalization | Targets |
|---|---|---|---|---|---|---|---|
| DR | WARS | 1.31E-04 | 3.01E-07 | 4.42E-01 | 4.80E-01 | 94.4% | Tier 1 Target |
| HSPA1A | 4.96E-04 | 8.89E-01 | 1.45E-147 | NA | 0.0% | Tier 3 Target | |
| KLK8 | 1.10E-02 | 5.78E-01 | 1.45E-147 | 4.91E-02 | 78.3% | Tier 2 Target | |
| SIRPG | 1.46E-02 | 3.32E-04 | NA | NA | 80.7% | Tier 1 Target | |
| KLK11 | 4.35E-02 | 4.94E-01 | 1.30E-01 | 6.01E-01 | 1.0% | Tier 3 Target | |
| PDR | OLFML3 | 3.75E-03 | 2.19E-02 | 1.08E-01 | NA | 0.0% | Tier 3 Target |
| ALDOC | 5.48E-03 | 9.28E-06 | NA | NA | 99.2% | Tier 1 Target | |
| SIRPG | 4.73E-02 | 6.65E-05 | NA | NA | 93.4% | Tier 1 Target |