Table 1.

Heterogeneity and pleiotropy analysis of MR.

Exposure	Analysis	Methods	Effect size	P value
Phospholipids in medium HDL	Heterogeneity	Cochran’s Q test	7.501 (QIVW)	0.277
			7.418(QMR Egger)	0.1914
	Pleiotropy	MR Egger regression	0.0051 (egger_intercept)	0.8224
Phospholipids in large HDL	Heterogeneity	Cochran’s Q test	11.4849 (QIVW)	0.7786
			8.7506 (QMR Egger)	0.8902
	Pleiotropy	MR Egger regression	0.0186 (egger_intercept)	0.119
Phospholipids in very large HDL	Heterogeneity	Cochran’s Q test	29.2373 (QIVW)	0.1084
			23.7268(QMR Egger)	0.2545
	Pleiotropy	MR Egger regression	0.0188(egger_intercept)	0.0435