Fig. 3.

Metabolic signatures in medulloblastoma RNA expression profiles. a,b) GSEA analysis of pathways enriched in each medulloblastoma group using the KEGG pathway database (WNT: n = 6, SHH: n = 14, Group3: n = 17, Group4: n = 17). a) KEGG pathways significantly enriched in each group using gene set enrichment analysis (GSEA). There were no significantly enriched KEGG pathways in Group4. b). Enrichment plots for enriched metabolic pathways in each group. c) Differences in mRNA expression of metabolic enzymes are associated with alterations in concentration of their associated metabolites. d) Heatmap representing clustered mRNA expression levels of genes constituting the ‘Alanine, aspartate and glutamate metabolism’ KEGG pathway.