Fig. 3.

Representative model fits with patients experiencing monophasic, biphasic and flat-partial response in HDV.

We see that the viral load, V, shows excellent agreement with the measured data. We further see that the biphasic decline in viral load is explained by a larger cell population I₁, which experiences fast clearance, together with a smaller cell population I₂, experiencing slower clearance. Likewise, ALT and HBsAg are well described by our model. Model fit values are in Table 1. Fitting curves of all patients are shown in Fig. S2. ALT, alanine aminotransferase; BLV, bulevirtide; HBsAg, hepatitis surface antigen; HDV, hepatitis D virus; LLoQ, lower limit of quantification; TND, target not detected.