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. 2024 Jan 15;98:129596. doi: 10.1016/j.bmcl.2023.129596

Table 1.

In vitro anti-TB inhibitory activity and cytotoxicity of aryl fluorosulfate 3a-3j

graphic file with name fx1.jpg

.
Compound Phenyl A Phenyl B Anti-TB activity
 Cytotoxicity
H37Rv MIC (µM) CDC1551 IC90 (µM) HEK293T CC50 (µM) HepG2 CC50 (µM)
3a graphic file with name fx2.gif graphic file with name fx3.gif 2.84 4.71 11.6 19.3
3b graphic file with name fx4.gif graphic file with name fx2.gif 25 >30 >40 13.3
3c graphic file with name fx6.gif graphic file with name fx7.gif ND 4.64 3.7 5.8
3d graphic file with name fx8.gif graphic file with name fx9.gif 0.6 1.3 22.7 12.5
3e graphic file with name fx10.gif graphic file with name fx11.gif 2.5 ND 16.8 17.6
3f graphic file with name fx2.gif graphic file with name fx13.gif 1.25 ND 18.8 22.4
3 g graphic file with name fx8.gif graphic file with name fx15.gif 10 ND 34.8 >40
3 h graphic file with name fx8.gif graphic file with name fx17.gif 1.25 ND 21.6 29.5
3i graphic file with name fx2.gif graphic file with name fx19.gif 0.6 ND >40 5.8
3j graphic file with name fx20.gif graphic file with name fx21.gif 5 ND >40 >40

ND = not determined.