Skip to main content
. 2024 Jan 15;98:129596. doi: 10.1016/j.bmcl.2023.129596

Table 2.

In vitro anti-TB inhibitory activity and cytotoxicity of aryl fluorosulfates 3j, 3i-3o, and 19a-19 m

graphic file with name fx22.jpg

.
Compound Heterocyclic ring C Anti-TB activity
 Cytotoxicity
H37Rv MIC (µM) HEK293T CC50 µM) HepG2 CC50 (µM)
3i graphic file with name fx23.gif 0.6 >40 5.8
3 k graphic file with name fx24.gif 1.23 >40 >40
3 l graphic file with name fx25.gif 0.16 27.7 17.0
3 m graphic file with name fx26.gif 0.22 >40 >40
19a graphic file with name fx27.gif 0.9 14.7 19.3
19b graphic file with name fx28.gif 1.25 ND >40
19c graphic file with name fx29.gif 0.84 31.7 18.5
19d graphic file with name fx30.gif 0.3 >40 30.14
19e graphic file with name fx31.gif 1.25 26.0 13.7
19f graphic file with name fx32.gif 0.37 9.65 8.63
19 g graphic file with name fx33.gif 0.45 13.2 12.1
19 h graphic file with name fx34.gif 5 >40 >40
19i graphic file with name fx35.gif 0.62 >40 >40
19j graphic file with name fx36.gif 0.78 23.8 6.99