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. 2024 Jan 11;11:1306002. doi: 10.3389/fbioe.2023.1306002

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Copyright © 2024 Kim, Riehl, Bouzid, Yang, Duan, Donahue and Lim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cyclic stretch induction of MSC osteogenic transcription and differentiation is impaired by YAP silencing. (A,B) MSCs were stretched without or with YAP siRNA, and the key osteogenic transcription factor, RUNX2, was assessed by western blotting on day 7 (n = 4). YAP siRNA was given with the start of the osteogenic induction and stretch. (C) Osteogenic gene expressions by qRT-PCR on day 7. (D,E) Alizarin red bone mineral staining on day 21 (n = 3). For (C–E), control (no stretch) and stretch without YAP siRNA was tested under control siRNA. NS: non-significant; *: p < 0.05 and **: p < 0.01 compared with control or corresponding counterpart; ^#: p < 0.05, ^##: p < 0.01, and ^###: p < 0.001 for comparison between stretch vs. stretch + YAP siRNA.