Table 6.

Schedule of enrolment, intervention, and assessments (as per SPIRIT [22])

¹PCT will be repeated after 6 to 24 hours in all admitted patients who did not receive antibiotics because of a low PCT value and in those in whom the algorithm was overruled

²In the subgroup of patients discharged home without antibiotics: phone evaluation after 48 hours

³Study D7, D28 and D90 are done by phone by the study team

⁴Biobanking of plasma, whole blood, paxgene tubes, urine, nasopharyngeal and oral swabs and sputa

⁵Urine biobanking (urine metabolites) in a subgroup of patients

⁶Optional interview for qualitative assessment of acceptability of the algorithm in a subgroup of patients