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. 2024 Jan 6;9(3):3642–3668. doi: 10.1021/acsomega.3c07655

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© 2024 The Authors. Published by American Chemical Society

Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).

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Photomicrographs of myocardial tissues from all experimentally treated groups (H&E staining, 10× magnification). (A) Negative control group showed normal cardiac architecture. (B) ISO-administered group exhibited (a) necrosis accompanied by (b) inflammatory cell infiltration and (c) local tissue interstitial edema (black arrows). The groups (C) Verapamil, (D) Carvedilol, (E) Fip.Cr 100 mg/kg, and (F) Fip.Cr 200 mg/kg ameliorated ISO-induced myocardial infarction damage, as shown by a substantial decrease in histological abnormalities. (G) Fip.Cr 200 mg/kg without isoprenaline-induced MI group exhibited no major histopathological alterations compared to the control group.