Table 2. Evaluating Body Weight and Weight Gain Percentage in Acute and Subacute Toxicity Studies of Rats with Fip.Cr Treatmenta.
| acute toxicity |
subacute toxicity |
|||||||
|---|---|---|---|---|---|---|---|---|
| parameters | normal control group | 1000 mg/kg | 1500 mg/kg | 2000 mg/kg | normal control group | 125 mg/kg | 250 mg/kg | 500 mg/kg |
| Body Weight | ||||||||
| initial weight (g) | 191 ± 18.40 | 187 ± 12.83 | 193.2 ± 14.92 | 188 ± 10.54 | 194.2 ± 14.72 | 185.4 ± 11.28 | 183.8 ± 7.29 | 185.8 ± 6.72 |
| 7th day (g) | 202 ± 21.45 | 196.6 ± 12.01 | 197.8 ± 17.88 | 193.4 ± 11.63 | 201.4 ± 16.99 | 195 ± 10.49 | 191 ± 10.98 | 192 ± 7.62 |
| 14th day (g) | 210.8 ± 23.48 | 205.4 ± 13.35 | 204.6 ± 17.56 | 200.6 ± 12.42 | 210 ± 18.43 | 200 ± 12.69 | 202.2 ± 11.34 | 203.4 ± 6.19 |
| 21st day (g) | 222.8 ± 16.86 | 210.2 ± 12.87 | 210.8 ± 9.731 | 213.4 ± 10.24 | ||||
| 28th day (g) | 236.8 ± 16.90 | 219.6 ± 13.26 | 222.4 ± 11.48 | 226 ± 9.43 | ||||
| Body Weight Gain | ||||||||
| 7th day (%) | 5.69 ± 2.15 | 5.19 ± 2.20 | 2.30 ± 1.8 | 2.87 ± 2.19 | 3.66 ± 1.48 | 5.23 ± 2.57 | 3.88 ± 2.75 | 3.34 ± 1.89 |
| 14th day (%) | 10.27 ± 3.13 | 9.91 ± 3.28 | 5.88 ± 2.95 | 6.73 ± 3.96 | 8.06 ± 2.25 | 7.89 ± 2.99 | 9.99 ± 4.10 | 9.53 ± 2.62 |
| 21st day (%) | 14.73 ± 1.49 | 13.41 ± 3.59 | 14.74 ± 4.61 | 14.98 ± 7.12 | ||||
| 28th day (%) | 21.98 ± 2.47 | 18.51 ± 4.58 | 21.01 ± 4.4 | 21.75 ± 6.53 | ||||
(n = 5) Values are reported as mean ± standard deviation. One-way ANOVA followed by Dunnett’s t test for statistical analysis. *p < 0.05 compared to the control group.