Table 4. Effects on Hematological and Biochemical Parameters of Fip.Cr’s Acute and Subacute Toxicities Assessments in Ratsa.
| acute toxicity |
subacute toxicity |
||||||
|---|---|---|---|---|---|---|---|
| parameters | normal control group | 1000 mg/kg | 1500 mg/kg | 2000 mg/kg | 125 mg/kg | 250 mg/kg | 500 mg/kg |
| TLC/WBC count × 103/μL | 6.29 ± 1.32 | 5.90 ± 1.32 | 6.78 ± 1.79 | 6.29 ± 1.19 | 5.98 ± 1.48 | 6.88 ± 2.19 | 6.72 ± 1.63 |
| RBC count × 106/μL | 7.52 ± 0.59 | 7.82 ± 1.10 | 8.05 ± 0.38 | 8.15 ± 0.93 | 7.77 ± 0.92 | 7.83 ± 0.99 | 8.16 ± 1.22 |
| hemoglobin (Hb%) g/dL | 13.7 ± 1.00 | 14.4 ± 0.96 | 13.1 ± 1.09 | 12.5 ± 1.45 | 14.2 ± 2.10 | 12.8 ± 1.97 | 13.3 ± 1.29 |
| HCT (PCV) % | 41.5 ± 3.53 | 41.7 ± 1.67 | 42.0 ± 3.04 | 44.9 ± 2.93 | 42.2 ± 2.61 | 40.7 ± 2.54 | 43.2 ± 4.32 |
| MCV fL | 53.4 ± 1.26 | 54.9 ± 2.15 | 55.4 ± 1.93 | 54.6 ± 1.42 | 54.1 ± 1.61 | 54.7 ± 2.21 | 56.3 ± 3.00 |
| MCH Pg | 18.0 ± 1.21 | 18.8 ± 1.86 | 19.3 ± 1.44 | 18.5 ± 1.43 | 18.6 ± 1.41 | 18.9 ± 1.64 | 17.5 ± 1.93 |
| MCHC g/dL | 33.1 ± 2.35 | 33.6 ± 1.59 | 33.3 ± 2.27 | 33.3 ± 1.19 | 32.7 ± 1.76 | 32.2 ± 3.33 | 31.8 ± 1.69 |
| platelets × 103/μL | 729 ± 90.5 | 718 ± 76.4 | 859 ± 96.3 | 874 ± 108 | 709 ± 66.8 | 865 ± 112 | 878 ± 103 |
| neutrophils % | 26.71 ± 2.54 | 28.65 ± 3.77 | 27.71 ± 4.11 | 25.36 ± 5.6 | 26.09 ± 4.70 | 25.65 ± 2.72 | 23.48 ± 3.46 |
| lymphocytes % | 74.48 ± 3.47 | 72.68 ± 5.013 | 73.81 ± 2.974 | 76.68 ± 2.66 | 72.67 ± 4.05 | 75.11 ± 3.6 | 77.54 ± 2.113 |
| monocytes % | 0.75 ± 0.11 | 0.78 ± 0.21 | 0.83 ± 0.13 | 0.86 ± 0.14 | 0.88 ± 0.29 | 0.90 ± 0.25 | 0.92 ± 0.14 |
| eosinophils % | 1.14 ± 0.29 | 1.02 ± 0.22 | 1.05 ± 0.21 | 1.13 ± 0.14 | 1.03 ± 0.34 | 1.07 ± 0.24 | 1.10 ± 0.20 |
| glucose random mg/dL | 83.40 ± 5.77 | 82.40 ± 2.79 | 79.20 ± 4.03 | 77.00 ± 2.92 | 81.40 ± 4.67 | 80.00 ± 7.65 | 78.60 ± 3.91 |
| bilirubin total mg/dL | 0.75 ± 0.21 | 0.76 ± 0.15 | 0.73 ± 0.11 | 0.69 ± 0.13 | 0.78 ± 0.16 | 0.77 ± 0.13 | 0.74 ± 0.17 |
| SGPT (ALT) U/L | 53.20 ± 7.86 | 56.20 ± 6.26 | 58.80 ± 7.63 | 63.00 ± 4.85 | 54.40 ± 6.88 | 57.20 ± 4.60 | 61.20 ± 5.72 |
| SGOT (AST) U/L | 150.8 ± 11.08 | 147.6 ± 8.99 | 142.8 ± 11.43 | 140.2 ± 15.16 | 148.2 ± 13.39 | 144.4 ± 14.21 | 143.6 ± 16.86 |
| alkaline phosphatase U/L | 250.6 ± 4.62 | 254.8 ± 7.09 | 252.6 ± 4.83 | 244.2 ± 6.98 | 253.4 ± 6.39 | 251.8 ± 5.63 | 247.4 ± 8.62 |
| blood urea mg/dL | 20.60 ± 3.85 | 17.80 ± 4.09 | 14.20 ± 3.83 | 18.20 ± 5.54 | 19.40 ± 5.86 | 15.20 ± 2.59 | 19.20 ± 2.78 |
| serum creatinine mg/dL | 0.90 ± 0.09 | 0.88 ± 0.03 | 0.84 ± 0.04 | 0.79 ± 0.10 | 0.89 ± 0.06 | 0.86 ± 0.05 | 0.82 ± 0.07 |
| sodium mmol/L | 145.4 ± 4.88 | 149.4 ± 5.13 | 144.8 ± 5.45 | 146.8 ± 4.49 | 150.6 ± 6.88 | 147.2 ± 7.36 | 152.4 ± 5.77 |
| potassium mmol/L | 5.51 ± 0.88 | 4.47 ± 0.85 | 5.33 ± 0.54 | 5.49 ± 0.41 | 4.65 ± 0.46 | 5.74 ± 0.59 | 5.62 ± 0.76 |
| chloride mmol/L | 104.2 ± 5.45 | 110.4 ± 9.15 | 105.2 ± 6.02 | 99.20 ± 5.02 | 108.4 ± 8.65 | 107.2 ± 7.05 | 102.6 ± 6.43 |
| total cholesterol mg/dL | 87.80 ± 5.59 | 80.60 ± 3.78 | 83.80 ± 5.36 | 88.80 ± 4.15 | 79.60 ± 4.62 | 86.40 ± 7.34 | 91.40 ± 4.72 |
| triglycerides mg/dL | 120.4 ± 4.34 | 116.4 ± 5.27 | 112.0 ± 6.042 | 119.6 ± 4.88 | 118.2 ± 3.83 | 109.0 ± 9.35 | 115.2 ± 8.70 |
| LDL cholesterol mg/dL | 22.40 ± 3.44 | 20.80 ± 2.28 | 22.20 ± 3.11 | 26.60 ± 3.36 | 21.60 ± 2.7 | 23.40 ± 2.51 | 24.20 ± 4.21 |
| HDL cholesterol mg/dL | 49.40 ± 4.34 | 48.60 ± 3.85 | 51.20 ± 4.82 | 52.20 ± 4.49 | 50.00 ± 6.6 | 50.40 ± 5.94 | 53.80 ± 5.02 |
| total protein g/dL | 6.62 ± 0.51 | 5.9 ± 0.47 | 6.32 ± 0.64 | 7.14 ± 0.47 | 6.22 ± 0.29 | 6.92 ± 0.79 | 6.50 ± 0.66 |
| albumin g/dL | 3.22 ± 0.26 | 2.98 ± 0.28 | 3.32 ± 0.42 | 3.74 ± 0.54 | 3.54 ± 0.32 | 3.48 ± 0.46 | 3.70 ± 0.33 |
a
All data are means ± standard deviation (n = 5) and analyzed through one-way ANOVA followed by Dunnett’s t test compared with the normal control group. Values of *p < 0.05 were considered significant.