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. Author manuscript; available in PMC: 2024 Jan 25.
Published in final edited form as: Mol Cell Biochem. 2020 Jan 7;466(1-2):1–15. doi: 10.1007/s11010-019-03680-y

Fig. 10. Endo180 suppression further altered MMP-13, MMP-14, Col IIIA, and Col IV expression in Ang-II hypertension, which was restored by GYY.

Fig. 10

Fig. 10

Fig. 10

MCs and MGECs were transfected with scrambled siRNA (as negative control) and Endo 180 siRNA (10 nM, 48 hrs). Western blot analysis indicated suppression of Endo180 by siRNA in both the cell types (a). In siRNA transfected MCs (b) and MGECs (c), GYY (GYY4137) was added 1 h prior to the Ang-II treatment. Endo 180, MMP-13, -14, Col IIIA, and Col IV protein expressions were determined by Western blot. GAPDH was used as a loading control. Data are presented as mean ±SEM, n = 9 independent experiments / group. *,†, #p <0.05 vs respective controls; ns=non-significant difference of MMP-13 expression among these groups.