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. Author manuscript; available in PMC: 2024 Jan 25.
Published in final edited form as: Mol Cell Biochem. 2020 Jan 7;466(1-2):1–15. doi: 10.1007/s11010-019-03680-y

Fig. 11. Schematic of overall finding.

Fig. 11

In response to hypertensive stress, upregulated PAI-1 inhibited tPA resulting in Endo 180 downregulation both in MCs and MGECs. On the other hand, while TIMP-1 was downregulated in MCs, it was upregulated in MGECs during hypertensive stress conditions. Because of this differential TIMP-1 deregulation, an opposing effect on MMP-13 expression was also observed in these two cell lines; whereas, the expression of MMP-14 was upregulated in both the cells. Silencing expression of Endo 180 by siRNA alters Ang-II-induced MMP/Collagen remodeling in both cell types. Together, Endo 180 and MMP/TIMP imbalance contributed collagen deposition and ECM remodeling in MCs and MGECs.