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. 2024 Jan 25;21:10. doi: 10.1186/s12987-024-00511-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Zucker rat bodyweight and intracranial pressure. A Images of lean (left panel) and obese (right panel) Zucker rats. B Bodyweight increases as a function of time of Zucker lean (n = 15) and obese (n = 16) rats included in study. Error bars are within the symbols. C Rat bodyweight and D body mass index (BMI) at time of experimentation. E representative intracranial pressure (ICP) traces from Zucker lean and obese rats with the final 15 min recordings quantified in F, n = 5 of each. G Correlation analysis of ICP as a function of bodyweight in the tested Zucker rats. H Representative ICP trace with “raw” (blue line) and “smoothed” (red line) signals, the latter used to calculate the mean wave amplitude (MWA), represented in I (n = 5 of each). J Correlation analysis of MWA as a function of ICP, n = 10. Statistical significance evaluated with Student’s unpaired t-test or simple linear regression and results shown as mean ± SEM. ***p < 0.001, ns = not significant