Fig. 3.

The beneficial effect of SADI, but not SG, on glycemic control is independent of caloric restriction. A Evolution of glucose after oral glucose tolerance and C intraperitoneal insulin tolerance tests. B Bar graphs show the AUC in the oral glucose tolerance and D intraperitoneal insulin tolerance tests. Values are the mean ± SEM (n = 15–20/group). Differences were analyzed through one-way ANOVA followed by Bonferroni post hoc tests. ***p < 0.001 vs. sham-operated group; ^ΔΔΔp < 0.001 vs. SG group; ^§p < 0.05, ^§§p < 0.01, ^§§§p < 0.001 vs. PFD SADI-S rats. AUC, area under the curve; IPITT, intraperitoneal insulin tolerance test; OGTT, oral glucose tolerance test; PFD, pair-fed; SADI-S, single anastomosis duodeno-ileal bypass with sleeve gastrectomy; SG, sleeve gastrectomy