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. 2023 Dec 4;52(2):558–571. doi: 10.1093/nar/gkad1160

Figure 1.

Figure 1.

Multiple sequence alignment of Class I (top) and Class II (bottom) catalytic domains. One AlphaFold-generated representative was randomly selected from each family, provided that the reference structure contained all of the insertion modules which characterise the family. Helices are depicted by blue cylinders; β-strands by yellow arrows; all other secondary structural elements by black lines; and multiple sequence alignment gaps are left blank. For simplicity, when an extended helix or strand is interrupted by a single secondary structural element (such as a turn or a bend), that element is omitted from the diagram.