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. 2023 Nov 28;52(2):625–642. doi: 10.1093/nar/gkad1126

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — GR-regulated transcriptome is associated with AR pathways in antiandrogen-treated prostate cancer cells. (A-B) Box plots represent quantification of GR immunofluorescence (IF) in Dex-treated VCaP (A) or 22Rv1 (B) ENZ 0 or ENZ 3w cells. Data shown as mean nuclear intensity, VCaP: n = 15 images; 22Rv1: n = 30 images. Statistical significance calculated with unpaired t-test. (C) Bar graphs depict NR3C1 expression levels in VCaP and 22Rv1 ENZ 0 or ENZ 3w cells from RNA-seq data. Data shown as transcripts per million (TPM). Statistical significance calculated with unpaired t-test. (D) Venn diagrams of Dex-regulated genes in VCaP and 22Rv1 cells from RNA-seq data after Dex (blue circle) or ENZ + Dex (black circle) treatment. (E, F) Gene set enrichment analysis (GSEA) of Dex-regulated genes from VCaP (black) or 22Rv1 (orange) ENZ 3w cells at hallmark (E) or GO biological process (F) pathways. Data shown as normalized enrichment score (NES) with circle size depicting FDR q-value.