Table 2.

Comparisons of Anti-inflammatory Potency and Ocular Penetration of Topical Ocular Glucocorticoids

Glucocorticoid	Relative Anti-inflammatory Activity	Dose	Peak Aqueous Humor Concentration (ng/mL)	Time to Peak (minutes)	IOP Rise (mmHg)
Cortisol	1	0.5%			3.2
Prednisolone	4	1%	7650	30	10.0
Prednisolone Acetate	4	1%	670–1130	45–120
Prednisolone Phosphate	4	1%	26	90–240
Fluorometholone	40	0.1%	5.1	30–60	6.1
Dexamethasone	25	0.1%	31	90–120	22.0
Dexamethasone Phosphate	25	0.1%	31	55
Medrysone	4	1%			1.0
Loteprednol etabonate	25	0.5%	*	*
Rimexolone	25	1%			~6
Difluprednate emulsion	60	0.05%	30	60

^*Rapidly metabolized and inactivated in cornea (Druzgala P et al. PMID 1959381)[124]

Data from: Murdick PW, Keates RH, Donovan EF et al. (PMID: 5928150)[125]

Awan MA, Agarwal PK, Watson DG et al (PMID: 19293163)[126]

Razeghinejad MR, Katz L (PMID: 21757964)[127]

Yamaguchi M, Yasueda S et al (PMID: 16023810)[128]