Table 2.
Patient characteristics stratified by lymph node status
| Parameter | Total | N0 | N1 | N2 | P |
|---|---|---|---|---|---|
| 466 (100%) | 125 (27%) | 186 (40%) | 155 (33%) | ||
| Sex | |||||
| Male | 255 (54.7) | 65 (52.0) | 100 (53.8) | 90 (58.1) | 0.56 |
| Female | 211 (45.3) | 60 (48.0) | 86 (46.2) | 65 (41.9) | |
| Age (years), median (min-max) | 69.3 (32–93) | 70.4 (34–93) | 69.1 (32–90) | 68.5 (35–87) | 0.51 |
| Type of resection | |||||
| Pancreaticoduodenectomy | 309 (66.3) | 79 (63.2) | 117 (62.9) | 113 (72.9) | 0.057 |
| Distal pancreatectomy | 84 (18.0) | 29 (23.2) | 38 (20.4) | 17 (11.0) | |
| Total pancreatectomy | 73 (15.7) | 17 (13.6) | 31 (16.7) | 25 (16.1) | |
| T stage (AJCC, 8th edition) | |||||
| T1 | 61 (13.1) | 32 (25.6) | 20 (10.7) | 9 (5.8) | < 0.001 |
| T2 | 276 (59.2) | 73 (58.4) | 121 (65.1) | 82 (52.9) | |
| T3 | 105 (22.5) | 18 (14.4) | 38 (20.4) | 49 (31.6) | |
| T4 | 24 (5.2) | 2 (1.6) | 7 (3.8) | 15 (9.7) | |
| Tumour size, median (min-max) | 32 (1–190) | 30 (1–190) | 30 (10–110) | 35 (10–150) | < 0.001 |
| Tumour grading | |||||
| 1 | 48 (10.3) | 15 (12.0) | 19 (10.2) | 14 (9.0) | 0.61 |
| 2 | 238 (51.1) | 66 (52.8) | 95 (51.1) | 77 (49.7) | |
| 3 | 170 (36.5) | 42 (33.6) | 70 (37.6) | 58 (37.5) | |
| 4 | 3 (0.6) | 0 (0.0) | 2 (1.1) | 1 (0.6) | |
| Unknown | 2 (0.4) | 2 (1.6) | 0 (0.0) | 5 (3.2) | |
| Resection margin | |||||
| 0 | 153 (32.8) | 67 (53.6) | 55 (29.6) | 31 (20.0) | < 0.001 |
| 1 | 295 (63.3) | 54 (43.2) | 121 (65.0) | 120 (77.4) | |
| Unknown | 18 (3.9) | 4 (3.2) | 10 (5.4) | 4 (2.6) | |
| Adjuvant treatment | |||||
| Yes | 356 (76.4) | 97 (77.6) | 140 (75.3) | 119 (76.8) | 0.94 |
| No | 59 (12.7) | 14 (11.2) | 26 (14.0) | 19 (12.3) | |
| Unknown | 51 (10.9) | 14 (11.2) | 20 (10.8) | 17 (11.0) | |
| Overall survival (months), median | 22.7 | 52.3 | 19.8 | 16.5 | < 0.001 |
Values are n (%) unless otherwise stated. T1, size ≤ 2 cm; T2, size ≤4 cm; T3, size >4 cm; T4, infiltration of coeliac trunk, A. hepatica or A. mesenterica sup. R1, distance of the tumour < 1 mm to the resection margin.