Table 4.

Univariate analysis of prognostic factors for overall survival

Variable	HR	95% c.i.	P
Sex, female	0.854	(0694–1.050)	0.13
Age (years)	1.008	(1.008–1.018)	0.12
T stage (AJCC, 8th edition)
T1	1.0 (reference)		–
T2	2.29	(1.59–3.31)	< 0.001
T3	3.27	(2.19–4.89)	< 0.001
T4	5.03	(2.94–8.60)	< 0.001
Lymph node status
N0	1.0 (reference)		–
N1	2.35	(0.177–3.12)	< 0.001
N2	2.96	(2.21–3.95)	< 0.001
Tumour grade
G1	1.0 (reference)		–
G2	1.39	(0.96–2.02)	0.07
G3	1.93	(1.32–2.83)	< 0.001
Resection margin
R0	1.0 (reference)		–
R1	1.55	(1.23–1.95)	< 0.001