Table 5.

Multivariate analysis of prognostic factors for overall survival

Analysis: <21 examined lymph nodes				Analysis: <22 examined lymph nodes
Variable	HR	95% c.i.	P	Variable	HR	95% c.i.	P
T-stage: T3/T4	1.52	1.19–1.93	<0.001	T-stage: T3/T4	1.50	1.18–1.91	<0.001
Grading: G3/G4	1.44	1.16–1.79	<0.001	Grading: G3/G4	1.44	1.15–1.79	<0.001
R1-status*	1.26	0.99–1.60	0.051	R1-status*	1.27	0.99–1.53	0.051
Lymph node status				Lymph node status
N1	2.16	1.61–2.89	<0.001	N1	2.14	1.59–2.86	<0.001
N2	2.57	1.88–3.51	<0.001	N2	2.57	1.88–3.51	<0.001
<21 ELN	1.27	1.02–1.58	0.034	<22 ELN	1.23	0.99–1.60	0.061

*Defined as R0 ≥ 1 mm tumour-free resection margin. Adjusted Cox proportional hazard model, HR with 95 per cent c.i., examined lymph nodes (ELN).