FIG. 6.

Tissue biopsies from euthanized mice which were infected with 10⁶ CFU of either the SLS-producing wild-type MGAS166s (A) or the SLS-deficient Tn916 mutant SBNH5 (B). The tissue section in panel A demonstrates acute inflammation with edema and tissue necrosis. The tissue depicted in panel B does not show evidence of necrosis, and the inflammation is markedly reduced compared with that in panel A. Tissue samples were stained with hematoxylin and eosin, and the final magnification is approximately ×17.