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. Author manuscript; available in PMC: 2024 Mar 1.
Published in final edited form as: Clin Immunol. 2022 Dec 22;248:109213. doi: 10.1016/j.clim.2022.109213

Figure 4. Increased expression of pro-ferroptosis enzyme ACSL4 and tubular lipid peroxidation in the kidneys of nephritic mice.

Figure 4.

The expression of ACSL4, the enzymes that dictates the shape of lipid the ferroptosis executioner was significantly elevated (A-B). Compared to non-nephritic 8-week-old MRL/lpr females (C), the nephritic kidneys of MRL/lpr females stain more intensely for 4-HNE, a lipid peroxidation marker (D). Most of the staining is in the tubular segments, the area of iron accumulation. Scale bar = 50 μm. Statistical significance was determined by 2-tailed Mann-Whitney test. Data are plotted as mean ± SEM. *P < 0.05.