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. 2024 Jan 15;13(1):bio060261. doi: 10.1242/bio.060261

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© 2024. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Aging induces a progressive shift in the spatial pattern of Notch transcriptional activation. (A) The percentage of cells containing at least one sygl-1 ATS was plotted as a function of the distance from the distal end of the gonad for each age to estimate the probability of Notch-dependent transcriptional activation in each position relative to the distal end. The red dashed line marks the proximal boundary of the GSC pool, where the percentage is below 2.5%. n=27, 25, 26, and 24 gonads for Day 1, 2, 3, and 4 respectively. (B,C) Line plots of the percentage of cells containing at least one sygl-1 ATS against the distance from the distal end of individual gonads overlaid at Day 1 (B) or Day 4 (C). (A) is the average of all these individual plots. The orange dashed line indicated the average peak of all the percentage of cells containing at least one sygl-1 ATS. (D) The individual sygl-1 ATS intensities are plotted against the distance from the distal end of Day 1 and 4. Each dot represents one sygl-1 ATS. n=931 and 550 ATS for Day 1 and 4, respectively.