Table 2.

Pregnancy Outcomes by Maternal TBI Status

	TB Uninfected	TBI	Crude Analysis			Adjusted Analysis			Expanded Adjusted Analysis
Categorical outcomes	N (%)	N (%)	COR	95% CI	P	AOR	95% CI	P	AOR	95% CI	P
Stillbirth	51 (0.51)	28 (1.1)	2.16	1.34–3.40	.001	1.90	1.13–3.21	.016	1.97	1.00–3.91	.051
Neonatal death	7 (0.09)	4 (0.22)	2.35	.62–7.81	.17	1.90	.54–6.68	.32	2.98	.57–15.6	.20
Preeclampsia	246 (2.5)	83 (3.3)	1.33	1.03–1.70	.028	1.27	.79–2.04	.32	1.22	.65–2.26	.54
Severe preeclampsiaa	103 (1.0)	44 (1.7)	1.68	1.17–2.38	.004	1.62	1.03–2.56	.036	1.85	.98–3.49	.060
Emergency cesarean section	1119 (11.3)	344 (13.6)	1.23	1.08–1.40	.002	1.28	1.02–1.63	.033	1.68	1.23–2.28	.0009
Placental ablation	37 (0.4)	13 (0.5)	1.37	.70–2.52	.33	1.34	.61–2.98	.46	1.41	.62–3.24	.41
Polyhydramnios	55 (0.6)	21 (0.8)	1.50	.88–2.44	.12	1.29	.65–2.58	.47	1.40	.60–3.23	.43
Oligohydramnios	283 (2.9)	73 (2.9)	1.01	.77–1.30	.95	.91	.66–1.25	.56	1.02	.67–1.53	.94
Low birthweightb	319 (4.2)	97 (5.3)	1.26	1.00–1.59	.049	1.38	1.01–1.88	.041	1.38	.96–1.98	.080
Prematurityc	356 (4.7)	97 (5.3)	1.13	.89–1.42	.29	1.23	.92–1.64	.16	1.32	.96–1.81	.087
IUGRd	486 (4.9)	126 (5.0)	1.01	.83–1.23	.90	1.04	.79–1.36	.79	1.18	.82–1.69	.38
Continuous outcomes	Value	Value	Diff.	95% CI	P	Adj. diff.	95% CI	P	Adj. diff.	95% CI	P
Birthweight (g), mean (SD)	3407 (560)	3424 (607)	16	−13–45	.27	−3.5	−37–30	.84	−11	−48–26	.56
Birthweight 2nd percentile	2094	1866	−228	−514–34	.086	−145	−426–136	.31	−269	−412 – −124	.0003
Birthweight 3rd percentile	2345	2155	−190	−323 – −57	.0052	−210	−333 – −87	.0008	−191	−336 – −48	.009
Birthweight 5th percentile	2570	2460	−110	−244–24	.10	−114	−237–9	.0069	−119	−240–1	.052
Birthweight 10th percentile	2790	2760	−30	−85–25	.10	−62	−123 – −1	.045	−45	−98–8	.095
Gestation (wk), mean (SD)	39.7 (2.0)	39.7 (2.2)	0.00	−.10–.10	.98	−0.09	−.20–.02	.17	−0.11	−.23–.01	.10
Gestation 2nd percentile	34.6	34.0	−.60	−2.1–.99	.47	−1.29	−2.7–.16	.082	−1.27	−2.39 – −.15	.027
Gestation 3rd percentile	36.0	35.1	−.90	−1.89 – −.12	.026	−1.07	−1.89 – −.26	.0099	−1.14	−2.34–.05	.060
Gestation 5th percentile	37.0	36.9	−.10	−.73–.44	.63	−0.42	−.99–.13	.13	−0.57	−1.03 – −.11	.016
Gestation 10th percentile	38.0	37.9	−.10	−.40–.11	.27	−0.14	−.37–.09	.22	−0.20	−.44–.04	.11

Adjustments were made for maternal age and African origin, with random effects fitted for maternal study code to account for repeated observations. Because of missing data, the adjusted models excluded 481 (3.9%) pregnancies. The expanded adjusted analyses also include covariates maternal education, parity, body mass index, and smoking; because of missing data, 4964 (39.9%) pregnancies were excluded from these models. Quantile regression models for percentiles of birthweight and gestational age did not include random effects.

Abbreviations: Adj. diff., adjusted difference; AOR, adjusted odds ratio; CI, confidence interval; COR, crude odds ratio; Diff., crude difference; HELLP, hemolysis, elevated liver enzymes, low platelet count syndrome; ICD, International Classification of Disease; IUGR, intrauterine growth restriction; NA, not available; SD, standard deviation; SGA, small for gestational age; TB, tuberculosis; TBI, TB infection.

^aSevere preeclampsia, HELLP syndrome, or eclampsia. This model required parity to be categorized at 0 or >0 to allow model convergence.

^bIUGR defined by presence of ICD-10 code O365 (maternity care due to known or suspected IUGR).

^cLow birthweight was defined as birthweight <2500 g.

^dPrematurity was defined as gestational length <37 weeks.