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. 2023 Sep 12;78(1):202–209. doi: 10.1093/cid/ciad471

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© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — RSV-A and RSV-B neutralizing titers before and 1 month after RSVPreF3 OA or placebo administration, by coexisting medical conditions of interest (per-protocol population for immunogenicity). Graphs show respiratory syncytial virus (RSV) subtypes A and B neutralizing titers before (day 1) and 1 month after (day 31) administration of the AS01_E-adjuvanted RSV prefusion F protein–based vaccine (RSVPreF3 OA) or placebo for the subgroups of participants without any of the coexisting medical conditions of interest (no condition) or with at least 1 of these conditions (≥1 condition); conditions of interest were cardiorespiratory conditions (chronic obstructive pulmonary disease [COPD], asthma, any chronic respiratory or pulmonary disease [including COPD, asthma, and other conditions], chronic heart failure) and endocrine and metabolic conditions (diabetes mellitus type 1 or type 2 and advanced liver or renal disease) that are associated with an increased risk of severe RSV disease. Error bars depict 95% confidence intervals. Rectangles above the bars contain geometric mean increases (GMIs) from day 1 to day 31 with 95% confidence intervals. ED60, estimated dilution 60.