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. Author manuscript; available in PMC: 2024 Mar 14.
Published in final edited form as: Cold Spring Harb Perspect Med. 2024 Mar 1;14(3):a041328. doi: 10.1101/cshperspect.a041328

Fig 4.

Fig 4.

HRASQ61L causes ovarian hormone-dependent ER+ adenocarcinoma in rats but metaplastic carcinoma with heavy squamous differentiation in mice. Lenti-HrasG61L was intraductally injected into adult FVB/n mice and Sprague Dawley rats. Mammary tumors appear within a few weeks in both groups of animals. Tumors in mice are metaplastic carcinoma with heavy squamous differentiation (also ER-negative). However, tumors in rats are adenocarcinoma with no evidence of metaplasia, but with strong positivity for both ERĪ± and PR (not shown)(Bu and Li 2020). These ER+/PR+ tumors are also ovarian hormone dependent (Bu and Li 2020).